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Microbiology/Virology Antifungal Hexaconazole

Hexaconazole

Catalog No. T5966   CAS 79983-71-4
Synonyms: (-)-Hexaconazol, (-)-Hexaconazol

Hexaconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.

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Hexaconazole, CAS 79983-71-4
Pack Size Availability Price/USD Quantity
100 mg In stock 53.00
500 mg In stock 72.00
1 mL * 10 mM (in DMSO) In stock 57.00
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Purity 95.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Hexaconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.
Targets&IC50 Antifungal
In vitro Hexaconazole is fungicidal against the powdery mildews B. graminis and S. cucurbitae on cucumber plants in a concentration-dependent manner and is curative against powdery mildew on barley plants when used at a concentration of 6.7 mg/L[1].It also inhibits growth of R. bataticola and S. rolfsii (ED50s = 6.35 and 1.27 mg/L, respectively)[2].
Cell Research
The medium was poured into a set of two petriplates under aseptic conditions in a laminar flow hood.When the medium in the plates was solidified, a mycelial disc of 0.5 cm diameter of freshly grown test fungi taken from periphery was inoculated upside down at the center of the plates.These treated petri dishes were incubated at 28℃ until fungal growth in the control plates was almost complete.Hexaconazole used as commercial fungicide and acetone served as control.All the compounds were tested in triplicates.The mycelia growth of fungi (mm) in both treated (T) and control (C) petri plates was measured diametrically in three different directions and growth inhibition (I) and corrected inhibition (IC) were calculated by using Abbott s formula[2]
Synonyms (-)-Hexaconazol , (-)-Hexaconazol
Purity 95.00%
Molecular Weight 314.21
Formula C14H17Cl2N3O
CAS No. 79983-71-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 100 mg/mL (318.26 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Tsuda M , Itoh H , Kato S . Evaluation of the systemic activity of simeconazole in comparison with that of other DMI fungicides[J]. Pest Management Science, 2004, 60(9):875-880. 2. Shakil N A , Kumar J , Pankaj, , et al. Synthesis and pesticidal activity of new N-alkyl-N-[1-(2-hydroxyphenyl) ethyl]amines[J]. Journal of Environmental Science and Health, Part B, 2009, 44(4):344-349.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Immunology/Inflammation Compound Library Antibiotics Library Anti-Fungal Compound Library Anti-Aging Compound Library

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