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Guanidinosuccinic acid

Catalog No. T7523 CAS 6133-30-8

Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine.

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Guanidinosuccinic acid Chemical Structure

Guanidinosuccinic acid, CAS 6133-30-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 41.00
25 mg	In stock	$ 67.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 148.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description

Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine.

In vivo

Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, was administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old.?Epileptogenic and toxic properties were assessed and GSA brain levels following i.p. injection were determined.?In adult mice, GSA induced long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n = 35), and an LD50 of 579 (445-756) mg/kg.?The CD50 of GSA corresponded with a brain concentration of 56 nmol/g tissue.?Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions.?When young mice were i.p. injected with a (for adults) subconvulsive dose of GSA (250 mg/kg), an age-dependent decrease was noted in GSA-induced convulsions and in the resulting brain concentration[1].

Molecular Weight	175.14
Formula	C5H9N3O4
CAS No.	6133-30-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 6 mg/mL (34.26 mM)

DMSO: 75 mg/mL (428.23 mM)

References and Literature

1. D"Hooge R , Pei Y Q , Marescau B , et al. Behavioral toxicity of guanidinosuccinic acid in adult and young mice[J]. Toxicology Letters (Shannon), 1992, 64 65(SPEC. ISSUE):773-777. 2. Kasai Y , Akanuma S I , Kubo Y , et al. Pharmacokinetics of Guanidinosuccinic Acid in Rat Blood and Cerebrospinal Fluid[J]. Drug Metabolism and Pharmacokinetics, 2014, 29(1):97-100.

Related compound libraries

This product is contained In the following compound libraries：

Human Endogenous Metabolite Library Natural Product Library Natural Product Library for HTS Human Endogenous Metabolite Compound Library Plus Gut Microbial Metabolite Library Human Metabolite Library NO PAINS Compound Library Bioactive Compounds Library Max RO5 Drug-like Natural Product Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Guanidinosuccinic acid 6133-30-8 Metabolism Others Endogenous Metabolite Inhibitor inhibit inhibitor

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