Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.
Description | Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes. |
Targets&IC50 | PKC:7.9 nM, PKCα:2.3 nM, PKCβ1:6.2 nM |
In vitro | 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2] |
Molecular Weight | 378.435 |
Formula | C24H18N4O |
CAS No. | 136194-77-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 45.0 mg/mL (118.9 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Go6976 136194-77-9 JAK/STAT信号通路 表观遗传 蛋白酪氨酸激酶 干细胞 微生物学 细胞骨架 血管生成 FLT Influenza Virus JAK PKC arrest inhibit Go 6976 Gö 6976 Protein kinase C Go-6976 cell Inhibitor inhibitor