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Go6976

Catalog No. T6515   CAS 136194-77-9
Synonyms: Gö 6976

Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.

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Go6976 Chemical Structure
Go6976, CAS 136194-77-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 78.00
5 mg In stock $ 192.00
10 mg In stock $ 285.00
25 mg In stock $ 482.00
50 mg In stock $ 687.00
100 mg In stock $ 955.00
1 mL * 10 mM (in DMSO) In stock $ 198.00
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Purity: 95.89%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.
Targets&IC50 PKCα:2.3 nM, PKC:7.9 nM, PKCβ1:6.2 nM, PKC:20 nM
In vitro 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2]
Synonyms Gö 6976
Molecular Weight 378.43
Formula C24H18N4O
CAS No. 136194-77-9

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (118.9 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Hayamitsu Adachi, et al. Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. The Journal of Antibiotics volume 71, pages 60–71 (2018). 2. Qatsha KA, et al. Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4674-8.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library TGF-beta/Smad Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Cytoskeletal Signaling Pathway Compound Library Anti-Viral Compound Library Anti-Cancer Compound Library

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Keywords

Go6976 136194-77-9 Chromatin/Epigenetic Cytoskeletal Signaling PKC Gö 6976 inhibitor inhibit

 

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