store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 78.00 | |
5 mg | In stock | $ 192.00 | |
10 mg | In stock | $ 285.00 | |
25 mg | In stock | $ 482.00 | |
50 mg | In stock | $ 687.00 | |
100 mg | In stock | $ 955.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes. |
Targets&IC50 | PKCα:2.3 nM, PKC:7.9 nM, PKCβ1:6.2 nM, PKC:20 nM |
In vitro | 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2] |
Synonyms | Gö 6976 |
Molecular Weight | 378.43 |
Formula | C24H18N4O |
CAS No. | 136194-77-9 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (118.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Go6976 136194-77-9 Chromatin/Epigenetic Cytoskeletal Signaling PKC Gö 6976 inhibitor inhibit