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Go6976

Catalog No. T6515   CAS 136194-77-9

Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.

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Go6976, CAS 136194-77-9
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.
Targets&IC50 PKC:7.9 nM, PKCα:2.3 nM, PKCβ1:6.2 nM
In vitro 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2]
Molecular Weight 378.435
Formula C24H18N4O
CAS No. 136194-77-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45.0 mg/mL (118.9 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hayamitsu Adachi, et al. Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. The Journal of Antibiotics volume 71, pages 60–71 (2018). 2. Qatsha KA, et al. Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4674-8.

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Keywords

Go6976 136194-77-9 JAK/STAT信号通路 表观遗传 蛋白酪氨酸激酶 干细胞 微生物学 细胞骨架 血管生成 FLT Influenza Virus JAK PKC arrest inhibit Go 6976 Gö 6976 Protein kinase C Go-6976 cell Inhibitor inhibitor