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Go6976

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Purity:95.89%

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COA HNMR HPLC

Go6976

Catalog No. T6515Cas No. 136194-77-9

Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.

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Pack Size	Price	Availability
1 mg	$78	In Stock
5 mg	$192	In Stock
10 mg	$285	In Stock
25 mg	$482	In Stock
50 mg	$687	In Stock
100 mg	$955	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description	Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.
In vitro	30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2]
Alias	Gö 6976

Chemical Properties

Molecular Weight	378.43
Formula	C24H18N4O
Cas No.	136194-77-9

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (118.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6425 mL	13.2125 mL	26.4250 mL	132.1248 mL
5 mM	0.5285 mL	2.6425 mL	5.2850 mL	26.4250 mL
10 mM	0.2642 mL	1.3212 mL	2.6425 mL	13.2125 mL
20 mM	0.1321 mL	0.6606 mL	1.3212 mL	6.6062 mL
50 mM	0.0528 mL	0.2642 mL	0.5285 mL	2.6425 mL
100 mM	0.0264 mL	0.1321 mL	0.2642 mL	1.3212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc