Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 3,548.00 |
Description | Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity. |
In vitro | Phytoestrogens, such as Glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. METHODS AND RESULTS: The osteogenic effects of Glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and Glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following Glycinol treatment. ER antagonist studies further support that Glycinol promotes osteogenesis through ER signaling. CONCLUSIONS: The results from these studies support investigating Glycinol as a potential preventive or treatment for osteoporosis. |
Source |
Molecular Weight | 272.25 |
Formula | C15H12O5 |
CAS No. | 69393-95-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Glycinol 69393-95-9 inhibitor inhibit