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Glycidamide

Catalog No. T31954 CAS 5694-00-8

Synonyms: LS1386, HSDB 7804, LS-1386, HSDB7804, HSDB-7804

Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations.

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Glycidamide, CAS 5694-00-8

Pack Size	Availability	Price/USD	Quantity
100 mg	Inquiry	$ 422.00
200 mg	Inquiry	$ 702.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations.

Synonyms	LS1386, HSDB 7804, LS-1386, HSDB7804, HSDB-7804
Molecular Weight	87.08
Formula	C3H5NO2
CAS No.	5694-00-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wang ET, Chen DY, Liu HY, Yan HY, Yuan Y. Protective effect of allicin against glycidamide-induced toxicity in male and female mice. Gen Physiol Biophys. 2015 Apr;34(2):177-87. doi: 10.4149/gpb_2014038. Epub 2015 Mar 2. PubMed PMID: 25730897. 2. Beland FA, Olson GR, Mendoza MC, Marques MM, Doerge DR. Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure. Food Chem Toxicol. 2015 Dec;86:104-15. doi: 10.1016/j.fct.2015.09.017. Epub 2015 Sep 30. PubMed PMID: 26429628; PubMed Central PMCID: PMC5066397. 3. Fennell TR, Snyder R, Hansen B, Friedman M. Dosimetry of Acrylamide and Glycidamide Over the Lifespan in a 2-Year Bioassay of Acrylamide in Wistar Han Rats. Toxicol Sci. 2015 Aug;146(2):386-94. doi: 10.1093/toxsci/kfv104. Epub 2015 Jul 3. PubMed PMID: 26141391; PubMed Central PMCID: PMC4517054. 4. Gutzkow KB, Duale N, Danielsen T, von Stedingk H, Shahzadi S, Instanes C, Olsen AK, Steffensen IL, Hofer T, Törnqvist M, Brunborg G, Lindeman B. Enhanced susceptibility of obese mice to glycidamide-induced sperm chromatin damage without increased oxidative stress. Andrology. 2016 Nov;4(6):1102-1114. doi: 10.1111/andr.12233. Epub 2016 Aug 30. PubMed PMID: 27575329.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glycidamide 5694-00-8 LS1386 HSDB 7804 LS-1386 LS 1386 HSDB7804 HSDB-7804 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.