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Glycerol phenylbutyrate

Name: Glycerol phenylbutyrate
Brand: TargetMol
SKU: T15393
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15393Cas No. 611168-24-2

Alias HPN-100

Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).

Glycerol phenylbutyrate

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Purity: 99.74%

Catalog No. T15393Alias HPN-100Cas No. 611168-24-2

Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$59	In Stock	In Stock
50 mg	$80	In Stock	In Stock
100 mg	$147	In Stock	In Stock
200 mg	$218	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.74%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Targets&IC50	σ2 receptor:pKi: 8.02
In vivo	Glycerol phenylbutyrate may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders. Glycerol phenylbutyrate also has the potential for the treatment of hyperammonemia. [1][2].
Synonyms	HPN-100

Chemical Properties

Molecular Weight	530.65
Formula	C₃₃H₃₈O₆
Cas No.	611168-24-2
Smiles	O=C(CCCc1ccccc1)OCC(COC(=O)CCCc1ccccc1)OC(=O)CCCc1ccccc1
Relative Density.	1.131 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (282.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8845 mL	9.4224 mL	18.8448 mL	94.2241 mL
5 mM	0.3769 mL	1.8845 mL	3.7690 mL	18.8448 mL
10 mM	0.1884 mL	0.9422 mL	1.8845 mL	9.4224 mL
20 mM	0.0942 mL	0.4711 mL	0.9422 mL	4.7112 mL
50 mM	0.0377 mL	0.1884 mL	0.3769 mL	1.8845 mL
100 mM	0.0188 mL	0.0942 mL	0.1884 mL	0.9422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc