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Glycerol phenylbutyrate

Catalog No. T15393 CAS 611168-24-2

Synonyms: HPN-100

Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).

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Glycerol phenylbutyrate Chemical Structure

Glycerol phenylbutyrate, CAS 611168-24-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 59.00
50 mg	In stock	$ 80.00
100 mg	In stock	$ 147.00
200 mg	In stock	$ 218.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.74%

Purity: 99.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Targets&IC50	σ2:pKi: 8.02
In vivo	Glycerol phenylbutyrate may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders. Glycerol phenylbutyrate also has the potential for the treatment of hyperammonemia. [1][2].

Synonyms	HPN-100
Molecular Weight	530.65
Formula	C33H38O6
CAS No.	611168-24-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (282.67 mM)

References and Literature

1. Rescifina A, et al. Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis. Eur J Pharm Sci. 2017 Aug 30;106:94-101. 2. Oishi K, et al. Glycerol phenylbutyrate for the chronic management of urea cycle disorders. Expert Rev Endocrinol Metab. 2014 Sep;9(5):427-434.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library EMA Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library GPCR Compound Library Pediatric Drug Library Approved Drug Library Bioactive Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glycerol phenylbutyrate 611168-24-2 GPCR/G Protein Sigma receptor inhibit HPN100 Inhibitor Sigma Receptor HPN 100 HPN-100 inhibitor

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