This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Glucagon (1-29), bovine, human, porcine
Catalog No. T15389 CAS
16941-32-5
Synonyms:
Porcine glucagon, Glucagon
Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
All TargetMol products are for research or drug registration purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose in violation of laws and regulations.
Glucagon (1-29), bovine, human, porcine, CAS 16941-32-5
Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
In vitro
Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia, after binding to its receptor Gcgr. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis [1]. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes and that also increases phosphorylation of HNF4α [3].
In vivo
Compared with PBS control, High-dose (1 mg/kg) Glucagon lowers glycemia and stimulates insulin secretion in ambient-fed mice. Low-dose (20 μg/kg) Glucagon enhances glycemia and does not stimulate insulin secretion in ambient-fed mice [4].
Synonyms
Porcine glucagon, Glucagon
Molecular Weight
3482.75
Formula
C153H225N43O49S
CAS No.
16941-32-5
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (14.36 mM),
Sonication is recommended.
H2O: 20 mg/mL (5.74 mM),
when pH is adjusted to 2 with HCl. Sonication is recommended.
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculator
Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
bottom
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.