Shopping Cart

Your shopping cart is currently empty

Galocitabine

Name: Galocitabine
Brand: TargetMol
SKU: T27399
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T27399Cas No. 124012-42-6

Alias RO-09-1390, RO-091390, RO091390, RO 091390, Neofrutulon

Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.

Galocitabine

Copy Product Info

😃Good

Purity: 99.89%

Catalog No. T27399Alias RO-09-1390, RO-091390, RO091390, RO 091390, NeofrutulonCas No. 124012-42-6

Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	In Stock	In Stock
5 mg	$201	In Stock	In Stock
10 mg	$273	In Stock	In Stock
25 mg	$415	In Stock	In Stock
50 mg	$559	In Stock	In Stock
100 mg	$735	In Stock	In Stock
200 mg	$973	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.89%

ee:100%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR CSFC FNMR ORP HPLC

Product Introduction

Bioactivity

Description	Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.
In vivo	We performed 4-week toxicity studies of capecitabine (N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorouridine), galocitabine (trimethoxybenzyl-5'-deoxy-5-fluorocytidine), 4 different fluoropyrimidine carbamate analogs. Four-week toxicity data for capecitabine in rats and mice were also obtained for comparison. Capecitabine, galocitabine, butyl, and isopentyl analogs showed similar toxicities in hematopoietic and intestinal organs at 1.0 mmol/kg. These compounds showed slight toxicity at 0.5 mmol/kg and no toxicity at 0.1 mmol/kg. [1]
Synonyms	RO-09-1390, RO-091390, RO091390, RO 091390, Neofrutulon

Chemical Properties

Molecular Weight	439.39
Formula	C₁₉H₂₂FN₃O₈
Cas No.	124012-42-6
Smiles	O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)N=C(NC(=O)C3=CC(OC)=C(OC)C(OC)=C3)C(F)=C2
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (113.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2759 mL	11.3794 mL	22.7588 mL	113.7941 mL
5 mM	0.4552 mL	2.2759 mL	4.5518 mL	22.7588 mL
10 mM	0.2276 mL	1.1379 mL	2.2759 mL	11.3794 mL
20 mM	0.1138 mL	0.5690 mL	1.1379 mL	5.6897 mL
50 mM	0.0455 mL	0.2276 mL	0.4552 mL	2.2759 mL
100 mM	0.0228 mL	0.1138 mL	0.2276 mL	1.1379 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc