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Gadolinium chloride

Catalog No. T22795   CAS 10138-52-0

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist

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Gadolinium chloride Chemical Structure
Gadolinium chloride, CAS 10138-52-0
Pack Size Availability Price/USD Quantity
25 mg In stock $ 41.00
50 mg In stock $ 53.00
100 mg In stock $ 82.00
200 mg In stock $ 128.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist
In vitro Gadolinium chloride (GdCl ) , a well-known Kupffer/foam cell inhibitor, at late stages of NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in vivo.?GdCl treatment successfully blocked the endocytic capacity of hepatic Kupffer/foam measured by India ink endocytosis, decreased the levels CD68-A marker of Kupffer cells in the liver-and normalized the transaminase levels in serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue of liver cells.?Gadolinium salts are widely used as magnetic resonance imaging (MRI) contrasts.?This study opens the possibility of targeting foam cells with gadolinium or by other means for improving NPC liver disease.?Synopsis: Gadolinium chloride can effectively rescue some parameters of liver dysfunction in NPC mice and its potential use in patients should be carefully evaluated.
Molecular Weight 263.61
Formula Cl3Gd
CAS No. 10138-52-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.5 mg/mL (28.45 mM), Sonication is recommended.

H2O: 9.85mg/mL

TargetMolReferences and Literature

1. Klein A D , JE Oyarzún, Cortez C , et al. Gadolinium Chloride Rescues Niemann–Pick Type C Liver Damage[J]. International Journal of Molecular Sciences, 2018, 19(11):3599.

TargetMolCitations

1. Zhao T, Zhong G, Wang Y, et al.Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin‐Induced Liver Injury.Advanced Science.2024: 2308771.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets
NPS-2143 hydrochloride Ronacaleret HCl SB-423562 Calhex 231 hydrochloride AC265347 CaSR antagonist-1 NPS-2143 Strontium ranelate

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Keywords

Gadolinium chloride 10138-52-0 GPCR/G Protein CaSR Gadolinium Chloride specific GdCl3 GdCl 3 GdCl-3 inhibit calcium-sensing receptor Inhibitor H9c2 cardiovascular Calcium-sensing receptor Gadolinium inhibitor

 

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