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GSK2033

Catalog No. T15427 CAS 1221277-90-2

GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).

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GSK2033, CAS 1221277-90-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 270.00
50 mg	In stock	$ 432.00
100 mg	In stock	$ 693.00
500 mg	In stock	$ 1,560.00
1 mL * 10 mM (in DMSO)	In stock	$ 127.00

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Purity: 99.05%

Biological Description

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Description	GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
Targets&IC50	LXRβ:7.4(pic50), LXRα:7 (pic50)
In vitro	GSK2033 dose-dependently inhibits basal transcription in full-length LXRα or full-length LXRβ cotransfection assays (IC50s: 17 nM and 9 nM, respectively). GSK2033 also effectively inhibits the transcription of an ABCA1 driven luciferase reporter dose-dependently (IC50s: 52 nM for LXRα and 10 nM for LXRβ). GSK2033 also suppresses the expression of both of fatty acid synthase (FASN) and SREBP1[2].
In vivo	GSK2033 (one month) treatment, does not have obviously effects on hepatic triglyceride levels. GSK2033 treatment also have no effects on plasma triglyceride levels[2].

Molecular Weight	591.66
Formula	C29H28F3NO5S2
CAS No.	1221277-90-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (50.70 mM), Sonication and heating are recommended.

References and Literature

1. Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6. 2. Griffett K, et al. Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428.

Citations

1. Liu Y, Wang Z, Jin H, et al.Squalene-epoxidase-catalyzed 24 (S), 25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity.Cell Reports.2024, 43(4).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Metabolism Compound Library Bioactive Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK2033 1221277-90-2 Metabolism Liver X Receptor Liver X receptor Inhibitor inhibit LXR GSK-2033 GSK 2033 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.