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GSK1702934A

Catalog No. T15425 CAS 924377-85-5

GSK1702934A is a selective TRPC3 agonist. It modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.

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GSK1702934A, CAS 924377-85-5

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Biological Description

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Description

GSK1702934A is a selective TRPC3 agonist. It modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.

In vitro

GSK1702934A induces transient, non-selective conductance and extends the duration of action potentials in TRPC3-overexpressing myocytes, an effect not observed in wild-type myocytes[2]. Furthermore, it effectively initiates TRPC3/6-currents in HEK293 cells expressing recombinant human TRPC3/6, with half-maximal effective concentrations (EC50) of 0.08 mM for TRPC3 and 0.44 mM for TRPC6, respectively[1]. Additionally, GSK1702934A significantly enhances NCX currents in TRPC3-overexpressing myocytes[2].

Molecular Weight	395.52
Formula	C22H25N3O2S
CAS No.	924377-85-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. de la Cruz GG, et al. Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core. Synlett. 2017 Apr;28(6):695-700. 2. Doleschal B, et al. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc Res. 2015 Apr 1;106(1):163-73.

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Keywords

GSK1702934A 924377-85-5 Others GSK-1702934A inhibitor inhibit

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