Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK J5 HCl is the hydrochloride form of GSK J5. GSK J5 is an inactive isomer of GSK J4 and a cell-permeable ester derivative of inactive control GSK J2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 261.00 | |
10 mg | Inquiry | $ 450.00 | |
50 mg | Inquiry | $ 1,895.00 |
Description | GSK J5 HCl is the hydrochloride form of GSK J5. GSK J5 is an inactive isomer of GSK J4 and a cell-permeable ester derivative of inactive control GSK J2. |
In vitro | KDM6B-specific pharmacological inhibitor GSK-J4 had a significant anti-proliferative effect in AML cell lines and freshly isolated BM monocytes (MNCs) from AML patients, while H3K27me3 levels were also increasing. GSK-J4 also caused apoptosis and cell cycle arrest in vitro, and reduced tumor burden in vivo in AML xenograft mouse models. |
In vivo | It is worth noting that the injection of GSK-J4 attenuated disease progression in a human AML xenograft mouse model. Treatment with GSK-J4 mainly resulted in the downregulation of DNA replication and cell cycle-related pathways and prevents the expression of HOX, a key cancer gene. ChIP-qPCR verified the increased H3K27me3 enrichment in the HOX gene transcription initiation site [1]. |
Synonyms | GSK J5 HCl |
Molecular Weight | 453.96 |
Formula | C24H28ClN5O2 |
CAS No. | T22820 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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GSK J5 HCl (1394854-51-3 free base) T22820 Others GSK J5 HCl (1394854 51 3 free base) 1394854-51-3 GSK J5 HCl (1394854513 free base) 1394854-51-3 free base GSK J-5 HCl (1394854-51-3 free base) GSK J5 HCl inhibitor inhibit