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GRL-0496

Catalog No. T9672 CAS 1087243-14-8

GRL-0496 is a potent inhibitor with an enzyme inhibitory activity against SARS-CoV 3CLpro with an IC50 of 30 nM and antiviral potency with an EC50 value of 6.9 μM.

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GRL-0496, CAS 1087243-14-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GRL-0496 is a potent inhibitor with an enzyme inhibitory activity against SARS-CoV 3CLpro with an IC50 of 30 nM and antiviral potency with an EC50 value of 6.9 μM.
Targets&IC50	SARS-CoV 3CLpro:30 nM, SARS-CoV:6.9 μM(EC50)

Molecular Weight	272.69
Formula	C14H9ClN2O2
CAS No.	1087243-14-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (366.72 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.

Related Products

Related compounds with same targets

Aplidine GRL-0496 HeE1-2Tyr RdRP-IN-2 SSAA09E3 Ledipasvir SARS-CoV-2-IN-13 CCF0058981

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GRL-0496 1087243-14-8 微生物学 SARS-CoV chloropyridyl 3CLpro inhibit GRL0496 Inhibitor GRL 0496 SARS coronavirus inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.