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GNE-375

Name: GNE-375
Brand: TargetMol
SKU: T27423
Price: 119 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27423Cas No. 1926989-06-1

Alias GNE375, GNE 375

GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.

GNE-375

🥰Excellent

Purity: 98.99%

Catalog No. T27423Alias GNE375, GNE 375Cas No. 1926989-06-1

GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.

Pack Size	Price	Availability
1 mg	$119	In Stock
5 mg	$293	In Stock
10 mg	$455	In Stock
25 mg	$745	In Stock
50 mg	$1,070	In Stock
100 mg	$1,570	In Stock
1 mL x 10 mM (in DMSO)	$332	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.99%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.
Targets&IC50	BRD9:5 nM
Synonyms	GNE375, GNE 375

Chemical Properties

Molecular Weight	451.51
Formula	C₂₅H₂₉N₃O₅
Cas No.	1926989-06-1
Smiles	COc1cc(c(OC)cc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12
Relative Density.	1.246 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (66.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2148 mL	11.0740 mL	22.1479 mL	110.7395 mL
5 mM	0.4430 mL	2.2148 mL	4.4296 mL	22.1479 mL
10 mM	0.2215 mL	1.1074 mL	2.2148 mL	11.0740 mL
20 mM	0.1107 mL	0.5537 mL	1.1074 mL	5.5370 mL
50 mM	0.0443 mL	0.2215 mL	0.4430 mL	2.2148 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc