Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 6,170.00 | |
50 mg | 10-14 weeks | $ 8,180.00 | |
100 mg | 10-14 weeks | $ 11,800.00 |
Description | Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic. |
Molecular Weight | 430.39 |
Formula | C19H27O9P |
CAS No. | 87810-56-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Fostriecin (free base) 87810-56-8 CI 920 CI-920 Fostriecin CI920 inhibitor inhibit