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Folic acid

Catalog No. T0062   CAS 59-30-3
Synonyms: Folate, Vitamin B9, Pteroylglutamic acid, Vitamin M, Folacin

Folic acid (Vitamin B9)(Vitamin M; Vitamin B9) is indispensable for the production and maintenance of new cells, for DNA/RNA synthesis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Folic acid Chemical Structure
Folic acid, CAS 59-30-3
Pack Size Availability Price/USD Quantity
500 mg In stock $ 45.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 98.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Folic acid (Vitamin B9)(Vitamin M; Vitamin B9) is indispensable for the production and maintenance of new cells, for DNA/RNA synthesis.
In vitro Folic acid treatment induces dose-related increases in BRCA1 mRNA expression in HepG2, Huh-7D12, Hs578T, and JURKAT and in BRCA2 in HepG2, Hs578T, MCF7, and MDA-MB-157 cells. FA does not affect the corresponding normal cells or on any of the ovarian cell lines. Folic acid induces increased BRCA1 protein expression in Hs578T, but not HepG2 cells, whereas BRCA2 protein levels are undetectable. FA treatment does not alter DNA repair in liver-derived cells, whereas there are transient effects on breast-derived cells. There is no effect of FA treatment on BRCA1 or BRCA2 DNA methylation, although there is some variation in the methylation of specific CpG loci between some cell lines[1].
Cell Research To determine the effect of FA supplementation on BRCA1 and BRCA2 mRNA expression, all cell lines were treated with 0, 25, 50, 75, or 100 nmol/L FA for 72 hours before harvesting in TRI Reagent according to the manufacturer’s instructions. (Only for Reference)
Source
Synonyms Folate, Vitamin B9, Pteroylglutamic acid, Vitamin M, Folacin
Molecular Weight 441.4
Formula C19H19N7O6
CAS No. 59-30-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (113.28 mM)

TargetMolReferences and Literature

1. Price RJ, et al. Nutr Res. 2015, 35(6):532-544. 2. Shin JH, et al. J Nutr. 1999, 129(11):2070-2073. 3. Liu C, Lai H, Chen T. Boosting Natural Killer Cell-Based Cancer Immunotherapy with Selenocystine/Transforming Growth Factor-Beta Inhibitor-Encapsulated Nanoemulsion[J]. ACS nano. 2020, 14(9): 11067-11082.

TargetMolCitations

1. Zhao Y, Li Y, Zhu R, et al.RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification.Signal Transduction and Targeted Therapy.2023, 8(1): 224. 2. Zhan X Z, Wei T H, Yin Y Q, et al.Determination and mechanism of Xiao-Ai Jie-Du decoction against diffuse large B-cell lymphoma: In silico and In vitro studies.Journal of Ethnopharmacology.2023: 117271. 3. Liu C, Lai H, Chen T. Boosting Natural Killer Cell-Based Cancer Immunotherapy with Selenocystine/Transforming Growth Factor-Beta Inhibitor-Encapsulated Nanoemulsion. ACS nano. 2020, 14(9): 11067-11082.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Tobacco Monomer Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Human Metabolite Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Liver Cancer Compound Library ReFRAME Related Library Natural Product Library for HTS Orally Active Compound Library

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Keywords

Folic acid 59-30-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DNA/RNA Synthesis Endogenous Metabolite Folate ntidepressant-like Vitamin B9 nutrient folic deficiency Vitamin B-9 inhibit Pteroylglutamic acid Vitamin M neural tube defects Inhibitor Folacin Vitamin B 9 inhibitor

 

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