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Fezagepras

Catalog No. T12883 CAS 1002101-19-0

Synonyms: PBI-4050, Setogepram

Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.

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Fezagepras, CAS 1002101-19-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 258.00
50 mg	In stock	$ 369.00
100 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Purity: 99.38%

Purity: 96.73%

Biological Description

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Storage & Solubility Information

Description	Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.
In vitro	TGF-β (10 ng/mL)-activated human hepatic stellate cells (HSCs) proliferation inhibited by Setogepram (PBI-4050; 500 μM; 24 hours). Setogepram (PBI-4050; 250 or 500 μM; 24hours) dose-dependently arrests HSCs at the G0/G1 phase without inducing apoptosis [2].
In vivo	In type 2 diabetes eNOS-/-db/db mice, Setogepram (PBI-4050; 100 mg/kg/day; gavage from 8-20 weeks of age) markedly decreases hyperglycemia and markedly improve glucose tolerance [1].

Synonyms	PBI-4050, Setogepram
Molecular Weight	206.28
Formula	C13H18O2
CAS No.	1002101-19-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (290.87 mM)

References and Literature

1. Li Y, et al. Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control. JCI Insight. 2018 May 17;3(10). pii: 120365. 2. Grouix B, et al. PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway. J Pharmacol Exp Ther. 2018 Oct;367(1):71-81.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library GPCR Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Orally Active Compound Library Clinical Compound Library Endocrinology-Hormone Compound Library Bioactive Compounds Library Max Preclinical Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Fezagepras 1002101-19-0 Endocrinology/Hormones GPCR/G Protein GPR PBI 4050 Free Fatty Acid Receptor PBI-4050 GPR84 inhibit PBI4050 FFAR G protein coupled receptor 84 Diabetes,Kidney,Renal,Pancreatic,Liver,Fibrosis,Nephrology Inhibitor Setogepram inhibitor

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