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Fengabine

Catalog No. T27310 CAS 80018-06-0

Synonyms: SL79229, SL 79.229-00, SL-79229, SL 79229, SL 79-229, SL 79,229-00

Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fengabine, CAS 80018-06-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 76.00
5 mg	In stock	$ 177.00
10 mg	In stock	$ 260.00
25 mg	In stock	$ 506.00
50 mg	In stock	$ 690.00
100 mg	In stock	$ 982.00
500 mg	In stock	$ 1,970.00

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Purity: 98.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.

In vivo

Fengabine (50-1000 mg/kg; i.p.) does not alter norepinephrine uptake but accelerates the turnover rate of norepinephrine in the rat brain as demonstrated by the enhancement of the alpha-methyl-p-tyrosine-induced disappearance of norepinephrine in the hypothalamus.[4]Fengabine (100 or 200 mg/kg; i.p., b.i.d.), given for 14 days, causes a desensitization of isoprenaline-stimulated adenylate cyclase in septal and cortical slices of the rat but fails to modify cortical beta, alpha-1 or alpha-2 adrenoceptor binding sites.[4]

Synonyms	SL79229, SL 79.229-00, SL-79229, SL 79229, SL 79-229, SL 79,229-00
Molecular Weight	322.23
Formula	C17H17Cl2NO
CAS No.	80018-06-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (139.65 mM)

References and Literature

1. Fairweather DB, et al. A placebo controlled double-blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers. Br J Clin Pharmacol. 1993 Mar;35(3):278-83. 2. Pitsiu M, et al. A comparison of the relative sensitivities of factor VII and prothrombin time measurements in detecting drug interactions with warfarin. Eur J Clin Pharmacol. 1992;42(6):645-9. 3. Aley KO, et al. Altered response to GABAergic agents following electro and chemo convulsions in mice. Indian J Exp Biol. 1991 Mar;29(3):241- 4. Scatton B, et al. Fengabine, a novel antidepressant GABAergic agent. II. Effect on cerebral noradrenergic, serotonergic and GABAergic transmission in the rat. J Pharmacol Exp Ther. 1987;241(1):251-257. 5. Ascalone V, et al. Determination of the GABAergic antidepressant drug fengabine and some of its metabolites in plasma by capillary gas chromatography with electron-capture detection. J Chromatogr. 1989;490(1):81-90. 6. Lloyd KG, et al. Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. J Pharmacol Exp Ther. 1987;241(1):245-250. 7. Aley KO, et al. Studies on the neuropsychopharmacological profile of fengabine (SL 79229) in mice. Methods Find Exp Clin Pharmacol. 1988;10(9):563-568.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fengabine 80018-06-0 Membrane transporter/Ion channel Neuroscience GABA Receptor SL79229 SL 79.229-00 SL-79229 SL 79229 SL 79-229 SL 79,229-00 inhibitor inhibit

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