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FK 866 hydrochloride (658084-64-1 free base)

Catalog No. T22785 CAS 1785666-54-7

Synonyms: FK 866 hydrochloride

FK 866 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (IC50: 0.09nM and 27.2nM).

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FK 866 hydrochloride (658084-64-1 free base) Chemical Structure

FK 866 hydrochloride (658084-64-1 free base), CAS 1785666-54-7

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 59.00
10 mg	Inquiry	$ 106.00
25 mg	Inquiry	$ 235.00
50 mg	Inquiry	$ 366.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 78.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	FK 866 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (IC50: 0.09nM and 27.2nM).
In vitro	In the vitro MTT assay using a panel of 41 human hematologic cancer cell lines, most cancer cells are sensitive to low concentrations of FK866. Among these cancer cells, AML cells are the most sensitive. FK866 is shown selective to human hematologic malignant cells and the normal human HPCs are resistant to FK866 treatment. It is found that FK866 induces cell death in a caspase-independent pathway but in a dose-dependent manner to induce mitochondrial membrane depolarization. Additionally, FK866 induces cell autophagy dependent on de novo protein synthesis. FK866 also reduces ATP levels in ML-2 cells due to the inhibition of NAD synthesis.
In vivo	The antitumor efficacy of FK866 is also shown in the in vivo models. FK866 significantly prevents tumor growth both in mice xenografted subcutaneously with AML-M4 and Namalwa cells. Furthermore, FK866 clears tumor cells to below detectable levels and results in 80% survival for the long-term [1].

Synonyms	FK 866 hydrochloride
Molecular Weight	427.97
Formula	C24H30ClN3O2
CAS No.	1785666-54-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: ≥18.95mg/mL

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FK 866 hydrochloride (658084-64-1 free base) 1785666-54-7 Others FK 866 Hydrochloride FK 866 hydrochloride (658084641 free base) 658084-64-1 free base 658084-64-1 FK 866 hydrochloride (658084 64 1 free base) FK866 Hydrochloride FK 866 hydrochloride FK-866 Hydrochloride inhibitor inhibit

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