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Ecamsule disodium

Catalog No. T41037 CAS 90458-75-6

Ecamsule disodium is a versatile UVA filter compound commonly employed in the formulation of sunscreen products. Its primary role is to mitigate the potential harm posed by solar radiation through the prevention of various biological repercussions induced by UV exposure. These include the inhibition of pyrimidine dimer formation, the reduction of p53 protein accumulation, and the downregulation of collagenase 2 expression.

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Ecamsule disodium, CAS 90458-75-6

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50 mg	5 days	Inquiry
100 mg	5 days	Inquiry

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Ecamsule, a broad-spectrum UVA-absorber with optimal absorbance at 344 nm, demonstrates increased sensitivity in wild-type Fibs E6/E7 cells at concentrations ranging from 200-1600 μM. It effectively mitigates UV and AAPH-induced ROS formation in fibroblasts, also reducing basal ROS levels in a dose-dependent manner. Maximum ROS reduction observed is 25.7% at 1600 μM under UV exposure. The same concentration decreases oxidative stress induced by AAPH by 10.8% and lowers basal ROS by 16.9%. Significantly, Ecamsule enhances cell viability at 1600 μM in AAPH-challenged cells.

Molecular Weight	585.68
Formula	C28H34NaO8S2
CAS No.	90458-75-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. 2. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ecamsule disodium 90458-75-6 Ecamsule inhibitor inhibit

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