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EL-102

Catalog No. T15205 CAS 1233948-61-2

Synonyms: EL102

EL-102 is a HIF1α inhibitor with anticancer activity that inhibits microtubule protein polymerization and can be used to study prostate cancer.

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EL-102, CAS 1233948-61-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
5 mg	In stock	$ 228.00
10 mg	In stock	$ 368.00
25 mg	In stock	$ 573.00
50 mg	In stock	$ 778.00
100 mg	In stock	$ 1,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 193.00

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Purity: 99.34%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	EL-102 is a HIF1α inhibitor with anticancer activity that inhibits microtubule protein polymerization and can be used to study prostate cancer.
Targets&IC50	PC3:37.0 nM, CWR22:24 nM, DLKP:14.4 nM, 22Rv1:21.7 nM, DU145 cells:40.3 nM, DLKPA:16.3 nM
In vitro	In CWR22, 22Rv1, DU145, PC-3, DLKP, and doxorubicin-selected variant DLKPA cell lines, EL-102 (0-120 nM; 72 hours) inhibited cell proliferation with IC50 values of 24, 21.7, 40.3, 37.0, 14.4, and 16.3 nM, respectively[1].
In vivo	In nude mice bearing CWR22 xenografts, EL-102 (oral gavage; 12 and 15 mg/kg; administered every 5 days with 2 days off) showed no effect on tumor growth but enhanced the effect of docetaxel on the tumor[1].

Synonyms	EL102
Molecular Weight	384.47
Formula	C19H16N2O3S2
CAS No.	1233948-61-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (52.02 mM), Sonication is recommended.

References and Literature

1. A P Toner et al. The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivoactivity against prostate cancer and circumvents MDR1 resistance. Br J Cancer, 2013 Oct 15, 109(8): 2131-2141.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EL-102 1233948-61-2 Angiogenesis Chromatin/Epigenetic Cytoskeletal Signaling Microtubule Associated HIF EL 102 EL102 inhibitor inhibit

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