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Droxidopa hydrochloride

Catalog No. T60369 CAS 1260173-94-1

Droxidopa (L-DOPS) hydrochloride is a potent, orally active precursor to norepinephrine that elevates standing blood pressure, mitigates orthostatic hypotension symptoms, and enhances standing capability. It holds promise for research in neurogenic orthostatic hypotension (nOH) and alternative attention deficit hyperactivity disorder (ADHD) treatments [1] [2] [3] [4].

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Droxidopa hydrochloride Chemical Structure

Droxidopa hydrochloride, CAS 1260173-94-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description

In vivo

Administering droxidopa hydrochloride (200 mg/kg; i.p.) modifies the activity of dopamine neurons and the prefrontal cortex, thereby enhancing attention-deficit/hyperactivity disorder (ADHD)-like behaviors in rats [2]. At dosages of 10 and 20 mg/kg (i.p.), it markedly increases paw withdrawal latency and mitigates mechanical hypersensitivity to thermal stimuli in 6-OHDA-lesioned rats five weeks post-surgery [3]. In an animal model using male Sprague-Dawley rats weighing 250-380g [2], a dosage of 200 mg/kg was administered, with a preceding benserazide injection (10 mg/kg, i.p.) 20 or 30 minutes before the L-DOPS infusion. This resulted in a significant reduction in the hyperactivity of BZ-pretreated SHR/NCrl rats at 30 minutes (P < 0.01) and 40 minutes (P < 0.05) post-injection, improved inattention-like behaviors, and lessened impulsive-like behaviors in both SHR/NCrl and Wistar rats.

Molecular Weight	249.65
Formula	C9H12ClNO5
CAS No.	1260173-94-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Droxidopa hydrochloride 1260173-94-1 inhibitor inhibit

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