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Dixyrazine

Catalog No. T19286 CAS 2470-73-7

Synonyms: UCB 3412

Dixyrazine （UCB 3412）has a transient antihypertensive effect, prevents cerebral edema induced by injections of ichthyosperm sulfate, and may be used in the study of neurologically related disorders.

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Dixyrazine, CAS 2470-73-7

Pack Size	Availability	Price/USD
1 mg	5 days	$ 197.00
2 mg	5 days	$ 269.00
5 mg	6-8 weeks	$ 413.00
10 mg	6-8 weeks	$ 662.00
25 mg	5 days	$ 1,090.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 388.00

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Purity: 97.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Pretreatment with Dixyrazine (10 mg/kg) completely prevents brain edema and significantly reduces the increase of albumin in cerebrospinal fluid (CSF)[2]. In conscious rats subjected to acute hypertension provoked by i.v. adrenaline or bicuculline, the phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of 126I labeled serum albumin. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, at a dose of 5 mg/kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). The maximum mean arterial pressure (MAP) is slightly but not significantly lower in Dixyrazine-treated rats[1].

Synonyms	UCB 3412
Molecular Weight	427.6
Formula	C24H33N3O2S
CAS No.	2470-73-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (187.09 mM), Sonication is recommended.

References and Literature

1. Johansson BB, et al. Phenothiazine-mediated protection of the blood-brain barrier during acute hypertension. Stroke. 1982 Mar-Apr;13(2):220-5. 2. Westergren I, et al. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate. Acta Neurochir (Wien). 1991;113(3-4):171-5.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dixyrazine 2470-73-7 Others UCB 3412 inhibitor inhibit

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