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Desisobutyryl-ciclesonide

Catalog No. T13646 CAS 161115-59-9

Synonyms: CIC-AP, Ciclesonide active principle

Desisobutyryl-ciclesonide has an affinity for glucocorticoid receptors. Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide.

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Desisobutyryl-ciclesonide Chemical Structure

Desisobutyryl-ciclesonide, CAS 161115-59-9

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Biological Description

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Description

Desisobutyryl-ciclesonide has an affinity for glucocorticoid receptors. Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide.

In vitro

Ciclesonide is an inhaled glucocorticoid with little affinity for glucocorticoid receptors. When converted into an active metabolite Desisobutyryl-ciclesonide, it is very effective in down-regulating the proinflammatory activity of airway parenchymal cells in vitro. 0.3-3.0μMCiclesonide and Desisobutyryl-Ciclesonide dose-dependently inhibited the proliferation of peripheral blood mononuclear cells to Candida albicans, but Desisobutyryl-Ciclesonide had a higher inhibitory effect. Significant proliferation of PhlP5 was observed only in cultures of ectopic subjects: effective downregulation has been detected at 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-Ciclesonide (at 3 μM Ciclesonide and 0.03 μM Desisobutyryl-ciclesonide Completely suppressed). 3μM Ciclesonide and Desisobutyryl-ciclesonide reduced the proportion of PhlP5-specific T cell embryonic cell proliferation and interleukin 4 producing cells. In PBMC cultures of atopic patients, both Csonide (CIC) and desisobutyryl-Crossonide (des-CIC) induced dose-dependent down-regulation of PhlP5-induced proliferation. At 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-Ciclesonide (p <0.001, each comparison), the effect is already significant (an earlier complete inhibition was observed at 3 μMCiclesonide and 0.03 μMDesisobutyryl-Ciclesonide. At 0.003 μM ( p<0.05), 0.03μM (p<0.001) and 0.3μM (p<0.05), the inhibitory activity of desisobutyryl-ciclesonide on PhlP5-induced PBMC proliferation was higher than that of Ciclesonide.

Synonyms	CIC-AP, Ciclesonide active principle
Molecular Weight	470.6
Formula	C28H38O6
CAS No.	161115-59-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (106.25 mM)

References and Literature

1. Silvestri M, et al. Ciclesonide modulates in vitro allergen-driven activation of blood mononuclear cells and allergen-specific T-cell blasts. Immunol Lett. 2012 Jan 30;141(2):190-6.

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Keywords

Desisobutyryl-ciclesonide 161115-59-9 Others Desisobutyryl ciclesonide CIC-AP Desisobutyrylciclesonide Ciclesonide active principle inhibitor inhibit

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