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Demeclocycline

Catalog No. T1400L CAS 127-33-3

Synonyms: Ledermycin, Bioterciclin, Deteclo, Declostatin, Deganol

Demeclocycline (Declostatin) is a tetracycline antibiotic produced by a strain of Streptomyces aureofaciens.Demeclocycline has antimicrobial activity and inhibits the action of vasopressin on the renal tubules, leading to diuresis. Demeclocycline can be used to induce diuresis and acute renal failure.

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Demeclocycline, CAS 127-33-3

Pack Size	Availability	Price/USD
1 mg	5 days	$ 38.00
5 mg	5 days	$ 82.00
10 mg	5 days	$ 118.00
25 mg	5 days	$ 193.00
50 mg	5 days	$ 286.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Demeclocycline (Declostatin) is a tetracycline antibiotic produced by a strain of Streptomyces aureofaciens.Demeclocycline has antimicrobial activity and inhibits the action of vasopressin on the renal tubules, leading to diuresis. Demeclocycline can be used to induce diuresis and acute renal failure.
In vitro	Demeclocycline (10 μM; 24 h) is a novel BTICs growth inhibitor, which can directly stimulate the activity of monocytes and macrophages[4].
In vivo	Demeclocycline (40 mg/kg; intraperitoneal injection; once daily; for 48 hours) resulted in increased urine volume, decreased urine osmolality, and significantly increased fractional excretion of water[3].

Synonyms	Ledermycin, Bioterciclin, Deteclo, Declostatin, Deganol
Molecular Weight	464.85
Formula	C21H21ClN2O8
CAS No.	127-33-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 20 mg/mL (43.02 mM), Sonication is recommended.

DMSO: 10 mg/mL (21.51 mM), Sonication is recommended.

References and Literature

1. I Chopra, et al. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29(3):245-77. 2. D Schnappinger, et al. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol. 1996 Jun;165(6):359-69. 3. Marleen L A Kortenoeven, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. 4. Susobhan Sarkar, et al. Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. Front Immunol. 2020 Feb 21;11:272.

Citations

1. Huang C Y, Nicholson M W, Wang J Y, et al. Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons. Cell Reports. 2022, 39(1): 110643

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Demeclocycline 127-33-3 Microbiology/Virology Antibacterial Ledermycin Bioterciclin Deteclo Declostatin Deganol inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.