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Deacylcortivazol

Catalog No. T23975 CAS 4906-84-7

Synonyms: UNII-3JO09QT49F, DAC, NSC 325316

Deacylcortivazol (DAC) is a potent glucocorticoid. When incubated with glucocorticoid-resistant mutants derived from the glucocorticoid-sensitive human leukemic cell line CEM-C7, DAC caused significant growth inhibition. The cytotoxicity of DAC at concentrations higher than necessary for glucocorticoid receptor saturation is not mediated by glucocorticoid receptors.

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Deacylcortivazol, CAS 4906-84-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	UNII-3JO09QT49F, DAC, NSC 325316
Molecular Weight	488.62
Formula	C30H36N2O4
CAS No.	4906-84-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Suino-Powell K, Xu Y, Zhang C, Tao YG, Tolbert WD, Simons SS Jr, Xu HE. Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol Cell Biol. 2008 Mar;28(6):1915-23. Epub 2007 Dec 26. PubMed PMID: 18160712; PubMed Central PMCID: PMC2268401. 2. Mrigank, Kothekar V. Computer stimulation of interaction of deacylcortivazol with d(TGTTCT)2. J Theor Biol. 1993 Jul 7;163(1):33-50. PubMed PMID: 8412241. 3. Harmon JM, Schmidt TJ, Thompson EB. Deacylcortivazol acts through glucocorticoid receptors. J Steroid Biochem. 1981 Mar;14(3):273-9. PubMed PMID: 6111624. 4. Harmon JM, Schmidt TJ, Thompson EB. Non-glucocorticoid receptor-mediated effects of the potent glucocorticoid deacylcortivazol. Cancer Res. 1982 Jun;42(6):2110-4. PubMed PMID: 6951631.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Deacylcortivazol 4906-84-7 UNII-3JO09QT49F DAC NSC-325316 NSC 325316 NSC325316 inhibitor inhibit

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