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Dabrafenib Mesylate

Catalog No. T8474   CAS 1195768-06-9
Synonyms: GSK2118436 Mesylate, GSK 2118436B, 达帕菲尼甲磺酸盐, 甲磺酸达拉非尼

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Dabrafenib Mesylate, CAS 1195768-06-9
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
Targets&IC50 BRafV600E:0.6 nM, CRAF:5 nM
In vitro In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM)[1]
Synonyms GSK2118436 Mesylate, GSK 2118436B, 达帕菲尼甲磺酸盐, 甲磺酸达拉非尼
Molecular Weight 615.66
Formula C24H24F3N5O5S3
CAS No. 1195768-06-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 34 mg/mL (55.22 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9. 2. Lee S, et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22.

Related compound libraries

This product is contained In the following compound libraries:
Autophagy Compound Library Anti-Cancer Metabolism Compound Library Glutamine Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Kinase Inhibitor Library MAPK Inhibitor Library Tyrosine Kinase Inhibitor Library

Related Products

Related compounds with same targets
Griffipavixanthone Pseudoginsenoside Rh2 I-37 GSK1904529A MCP110 Raf inhibitor 1 6H05 LY2452473

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dabrafenib Mesylate 1195768-06-9 MAPK信号通路 Raf Dabrafenib GSK 2118436B Raf kinases Inhibitor GSK2118436 inhibit GSK 2118436 GSK-2118436 GSK2118436 Mesylate inhibitor