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Dabrafenib Mesylate

Catalog No. T8474 CAS 1195768-06-9

Synonyms: GSK2118436 Mesylate, GSK 2118436B, 达帕菲尼甲磺酸盐, 甲磺酸达拉非尼

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Dabrafenib Mesylate, CAS 1195768-06-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
Targets&IC50	BRafV600E:0.6 nM, CRAF:5 nM
In vitro	In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM)[1]

Synonyms	GSK2118436 Mesylate, GSK 2118436B, 达帕菲尼甲磺酸盐, 甲磺酸达拉非尼
Molecular Weight	615.66
Formula	C24H24F3N5O5S3
CAS No.	1195768-06-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 34 mg/mL (55.22 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9. 2. Lee S, et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22.

Related compound libraries

This product is contained In the following compound libraries：

Autophagy Compound Library Anti-Cancer Metabolism Compound Library Glutamine Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Kinase Inhibitor Library MAPK Inhibitor Library Tyrosine Kinase Inhibitor Library

Related Products

Related compounds with same targets

Griffipavixanthone Pseudoginsenoside Rh2 I-37 GSK1904529A MCP110 Raf inhibitor 1 6H05 LY2452473

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dabrafenib Mesylate 1195768-06-9 MAPK信号通路 Raf Dabrafenib GSK 2118436B Raf kinases Inhibitor GSK2118436 inhibit GSK 2118436 GSK-2118436 GSK2118436 Mesylate inhibitor

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