Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 40.00 | |
10 mg | In stock | $ 57.00 | |
25 mg | In stock | $ 72.00 | |
50 mg | In stock | $ 85.00 | |
100 mg | In stock | $ 117.00 | |
500 mg | In stock | $ 238.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively). |
Targets&IC50 | BRafV600E:0.6 nM, CRAF:5 nM |
In vitro | In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM)[1] |
Synonyms | GSK 2118436B, GSK2118436 Mesylate |
Molecular Weight | 615.67 |
Formula | C24H24F3N5O5S3 |
CAS No. | 1195768-06-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 34 mg/mL (55.22 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Dabrafenib Mesylate 1195768-06-9 MAPK Raf Dabrafenib Raf kinases GSK 2118436B Inhibitor GSK2118436 inhibit GSK 2118436 Mesylate GSK2118436 Mesylate GSK 2118436 GSK-2118436 GSK-2118436 Mesylate inhibitor