Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
Description | Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively). |
Targets&IC50 | BRafV600E:0.6 nM, CRAF:5 nM |
In vitro | In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM)[1] |
Synonyms | GSK2118436 Mesylate, GSK 2118436B, 达帕菲尼甲磺酸盐, 甲磺酸达拉非尼 |
Molecular Weight | 615.66 |
Formula | C24H24F3N5O5S3 |
CAS No. | 1195768-06-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 34 mg/mL (55.22 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Dabrafenib Mesylate 1195768-06-9 MAPK信号通路 Raf Dabrafenib GSK 2118436B Raf kinases Inhibitor GSK2118436 inhibit GSK 2118436 GSK-2118436 GSK2118436 Mesylate inhibitor