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DMAT

Catalog No. T7390   CAS 749234-11-5
Synonyms: Casein kinase II Inhibitor, CK2 Inhibitor

DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).

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DMAT Chemical Structure
DMAT, CAS 749234-11-5
Pack Size Availability Price/USD Quantity
5 mg In stock $ 56.00
10 mg In stock $ 81.00
25 mg In stock $ 155.00
50 mg In stock $ 281.00
100 mg In stock $ 365.00
1 mL * 10 mM (in DMSO) In stock $ 90.00
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Purity: 99.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).
Targets&IC50 DYRK2:0.35 μM , CK2:0.13 μM (IC50, Human CK2) , HIPK3:0.59 μM , DYRK1A:0.41 μM , HIPK2:0.37 μM , Pim1:0.148 μM , PKD1:0.18 μM , Pim3:0.097 μM , CDK2:0.64 μM, Pim2:1.6 μM , DYRK3:1.7 μM
In vivo DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts[1][2].
Synonyms Casein kinase II Inhibitor, CK2 Inhibitor
Molecular Weight 476.79
Formula C9H7Br4N3
CAS No. 749234-11-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (104.87 mM), sonification is recommended.

TargetMolReferences and Literature

1. Lawnicka H , Kowalewicz-Kulbat M , Sicinska P , et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro[J]. Cell & Tissue Research, 2010, 340(2):371-379. 2. Sass, Gabriele. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT[J]. International Journal of Oncology, 2011, 39(2).

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Kinase Inhibitor Library Metabolism Compound Library Stem Cell Differentiation Compound Library Bioactive Compound Library Anti-Aging Compound Library NO PAINS Compound Library Wnt/Hedgehog/Notch Compound Library Bioactive Compounds Library Max Inhibitor Library

Related Products

Related compounds with same targets
IC261 Emodin CK1-IN-3 SR-3029 BioE-1115 (E/Z)-GO289 CKI-7 Casein kinase 1δ-IN-3

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Keywords

DMAT 749234-11-5 Metabolism Stem Cells Casein Kinase inhibit Casein kinase II Inhibitor Inhibitor CK2 Inhibitor inhibitor

 

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