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DL-threo dihydrosphingosine

Catalog No. T27189 CAS 2304-75-8

Synonyms: DL-Safingol, DTD, DL threo dihydrosphingosine

DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo dihydrosphingosine may be usefully employed to block smooth muscle cell proliferation.

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DL-threo dihydrosphingosine Chemical Structure

DL-threo dihydrosphingosine, CAS 2304-75-8

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,820.00
50 mg	8-10 weeks	$ 2,380.00
100 mg	8-10 weeks	$ 3,100.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	DL-Safingol, DTD, DL threo dihydrosphingosine
Molecular Weight	301.51
Formula	C18H39NO2
CAS No.	2304-75-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tolan D, Conway AM, Steele L, Pyne S, Pyne NJ. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br J Pharmacol. 1996 Sep;119(2):185-6. PubMed PMID: 8886394; PubMed Central PMCID: PMC1915874. 2. Meyer SG, de Groot H. Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. Biochim Biophys Acta. 2003 Dec 7;1643(1-3):1-4. PubMed PMID: 14654222. 3. Ma Y, She X, Yang S. Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (H₂O₂) levels in guard cells in Vicia faba. Sci China Life Sci. 2012 Nov;55(11):974-83. doi: 10.1007/s11427-012-4386-8. Epub 2012 Oct 22. PubMed PMID: 23090064. 4. Buehrer BM, Bell RM. Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways. J Biol Chem. 1992 Feb 15;267(5):3154-9. PubMed PMID: 1310683.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DL-threo dihydrosphingosine 2304-75-8 DLthreo dihydrosphingosine DL-Safingol DTD DL threo dihydrosphingosine inhibitor inhibit

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