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DA-11004

Catalog No. T23945 CAS 57404-51-0

Synonyms: DA11004, UNII-48M66E9ER2

DA-11004 is a potent NADP-dependent isocitrate dehydrogenase inhibitor (IC50: 1.49 μM for IDPc). DA-11004 inhibited fatty acid synthesis in adipose tissues via IDPc inhibition. It also decreased the plasma glucose levels and FFA in HF diet-induced obesity of C57BL/6J mice.

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DA-11004, CAS 57404-51-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	DA11004, UNII-48M66E9ER2
Molecular Weight	187.19
Formula	C11H9NO2
CAS No.	57404-51-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Shin CY, Jung MY, Lee IK, Son M, Kim DS, Lim JI, Kim SH, Yoo M, Huh TL, Sohn YT, Kim WB. Anti-diabetic effects of DA-11004, a synthetic IDPc inhibitor in high fat high sucrose diet-fed C57BL/6J mice. Arch Pharm Res. 2004 Jan;27(1):48-52. PubMed PMID: 14969338. 2. O'Dell LE, Parsons LH. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. J Pharmacol Exp Ther. 2004 Nov;311(2):711-9. Epub 2004 Jun 28. PubMed PMID: 15226384. 3. Lin D, Parsons LH. Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze. Pharmacol Biochem Behav. 2002 Apr;71(4):581-7. PubMed PMID: 11888549. 4. Parsons LH, Koob GF, Weiss F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32(2):132-5. PubMed PMID: 10231132.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DA-11004 57404-51-0 DA 11004 DA11004 UNII-48M66E9ER2 inhibitor inhibit

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