Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin (sodium salt) potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
250 μg | 35 days | $ 630.00 | |
1 mg | 35 days | $ 1,760.00 |
Description | Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin (sodium salt) potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5. |
Molecular Weight | 451.452 |
Formula | C21H33NaO7P |
CAS No. | 457070-06-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: Soluble
H2O: Soluble
DMSO: Soluble
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Cytostatin (sodium salt) 457070-06-3 Cytostatin inhibitor inhibit