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Cyclophostin

Catalog No. T27105 CAS 144773-26-2

Cyclophostin is an irreversible inhibitor of acetylcholinesterase (AChE).

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Cyclophostin, CAS 144773-26-2

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,820.00
50 mg	8-10 weeks	$ 2,380.00
100 mg	8-10 weeks	$ 3,100.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Cyclophostin is an irreversible inhibitor of acetylcholinesterase (AChE).

Molecular Weight	234.14
Formula	C8H11O6P
CAS No.	144773-26-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L. Cyclipostins and Cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo. J Biol Chem. 2018 Jan 4. pii: jbc.RA117.000760. doi: 10.1074/jbc.RA117.000760. [Epub ahead of print] PubMed PMID: 29301937. 2. Nguyen PC, Madani A, Santucci P, Martin BP, Paudel RR, Delattre S, Herrmann JL, Spilling CD, Kremer L, Canaan S, Cavalier JF. Cyclophostin and cyclipostins analogs, new promising molecules to treat mycobacterial-related diseases. Int J Antimicrob Agents. 2017 Dec 11. pii: S0924-8579(17)30435-1. doi: 10.1016/j.ijantimicag.2017.12.001. [Epub ahead of print] PubMed PMID: 29241819. 3. Nguyen PC, Delorme V, Bénarouche A, Martin BP, Paudel R, Gnawali GR, Madani A, Puppo R, Landry V, Kremer L, Brodin P, Spilling CD, Cavalier JF, Canaan S. Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. Sci Rep. 2017 Sep 18;7(1):11751. doi: 10.1038/s41598-017-11843-4. PubMed PMID: 28924204; PubMed Central PMCID: PMC5603573. 4. Martin BP, Vasilieva E, Dupureur CM, Spilling CD. Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin. Bioorg Med Chem. 2015 Dec 15;23(24):7529-34. doi: 10.1016/j.bmc.2015.10.044. Epub 2015 Oct 30. PubMed PMID: 26585276.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cyclophostin 144773-26-2 inhibitor inhibit

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