Powder: -20°C for 3 years
In solvent: -80°C for 6 months
Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. It has antibacterial, anti-inflammation, anti-tumor, antioxidant, renal protection.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | 179.00 | |
5 mg | Inquiry | 369.00 | |
10 mg | Inquiry | 612.00 | |
25 mg | Inquiry | 1219.00 | |
50 mg | Inquiry | 2029.00 | |
100 mg | Inquiry | 3239.00 |
Description | Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. It has antibacterial, anti-inflammation, anti-tumor, antioxidant, renal protection. |
In vitro | Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt [1]. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner [2]. |
In vivo | Cirsimaritin significantly reduces anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds [3]. |
Molecular Weight | 314.29 |
Formula | C17H14O6 |
CAS No. | 6601-62-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 6 months
DMSO: Soluble
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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