Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 88.00 | |
5 mg | In stock | $ 210.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 523.00 | |
50 mg | In stock | Inquiry |
Description | Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. |
In vitro | Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt [1]. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner [2]. |
In vivo | Cirsimaritin significantly reduces anxiety in mice. The high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg)[3]. |
Source |
Molecular Weight | 314.29 |
Formula | C17H14O6 |
CAS No. | 6601-62-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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Cirsimaritin 6601-62-3 Membrane transporter/Ion channel Neuroscience GABA Receptor γ-Aminobutyric acid Receptor inhibit Inhibitor Gamma-aminobutyric acid Receptor inhibitor