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Cirsimaritin

Catalog No. TQ0119 CAS 6601-62-3

Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. It has antibacterial, anti-inflammation, anti-tumor, antioxidant, renal protection.

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Cirsimaritin, CAS 6601-62-3

Pack Size	Availability	Price/USD
1 mg	Inquiry	179.00
5 mg	Inquiry	369.00
10 mg	Inquiry	612.00
25 mg	Inquiry	1219.00
50 mg	Inquiry	2029.00
100 mg	Inquiry	3239.00

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Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. It has antibacterial, anti-inflammation, anti-tumor, antioxidant, renal protection.
In vitro	Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt [1]. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner [2].
In vivo	Cirsimaritin significantly reduces anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds [3].

Molecular Weight	314.29
Formula	C17H14O6
CAS No.	6601-62-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Quan Z, et al. Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells. Cancer Lett. 2010 Sep 28;295(2):252-9. 2. Kim HJ, et al. Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. Int J Mol Sci. 2015 Apr 20;16(4):8772-88. 3. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59.

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