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ChX710

Catalog No. T13613 CAS 2438721-44-7

ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequence, and the phosphorylation of Interferon Regulatory Factor (IRF) 3.

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ChX710, CAS 2438721-44-7

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Purity: 98%

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Description	ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequence, and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
In vitro	The treatment of ChX710 efficiently prime the cellular response to DNA transfection via STING as assessed by strong synergistic effects on IFN-β expression at both transcriptional and protein levels.

Molecular Weight	323.39
Formula	C18H21N5O
CAS No.	2438721-44-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 20 mg/mL (61.84 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Khiar S, et al. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Sci Rep. 2017 May 31;7(1):2561.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ChX710 2438721-44-7 Immunology/Inflammation STING MPYS ERIS ChX 710 TMEM173 Inhibitor inhibit MITA Stimulator of Interferon Genes ChX-710 inhibitor

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