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Ceronapril

Catalog No. T25226 CAS 111223-26-8

Synonyms: Ceronaprilum, SQ 29852, SQ-29852, SQ29852

Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.

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Ceronapril, CAS 111223-26-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 628.00
5 mg	In stock	$ 1,350.00
10 mg	In stock	$ 1,730.00
50 mg	In stock	$ 2,180.00
100 mg	In stock	$ 2,800.00
500 mg	In stock	$ 5,590.00

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Purity: 95.27%

ee: 100%

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Description	Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.
In vivo	In male SD rats, Ceronapril (SQ 29852) inhibits ACE, with ED50 values of 0.063 μM/kg and 0.53 μM/kg for intravenous injection and oral administration, respectively [1]. Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) blocks ACE in peripheral sites of rats [2].[1].

Synonyms	Ceronaprilum, SQ 29852, SQ-29852, SQ29852
Molecular Weight	440.47
Formula	C21H33N2O6P
CAS No.	111223-26-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chen BZ, et al. Effect of acute and chronic administration of ceronapril on angiotensin converting enzyme in plasma, kidney, lung, brain regions and cerebrospinal fluid of rats. Neuropharmacology. 1992 Sep;31(9):929-35. 2. Karanewsky D S, et al. (Phosphinyloxy) acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl] oxy]-1-oxohexyl]-L-proline, a novel orally active inhibitor of ACE. Journal of medicinal chemistry, 1988, 31(1): 204-212. 3. Cutler NR, Sramek JJ, Luna A, Mena I, Brass EP, Kurtz NM, Brennan JJ. Effect of the ACE inhibitor ceronapril on cerebral blood flow in hypertensive patients. Ann Pharmacother. 1996 Jun;30(6):578-82. PubMed PMID: 8792940. 4. Tu JI, Brennan J, Stouffer B, Mantha S, Turabi N, Tsay HM. Radioimmunoassay for ceronapril, a new angiotensin-converting enzyme inhibitor, and its application to a pharmacokinetic study in healthy male volunteers. Ther Drug Monit. 1992 Jun;14(3):209-19. PubMed PMID: 1412607.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ceronapril 111223-26-8 Endocrinology/Hormones RAAS Ceronaprilum SQ 29,852 SQ 29852 SQ-29852 SQ29,852 SQ-29,852 SQ29852 inhibitor inhibit

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