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Ceronapril

Name: Ceronapril
Brand: TargetMol
SKU: T25226
Rating: 4.5 (1 reviews)

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Catalog No. T25226Cas No. 111223-26-8

Alias SQ-29852, SQ29852, SQ 29852, Ceronaprilum

Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.

Ceronapril

🥰Excellent

Purity: 97.94%

Catalog No. T25226Alias SQ-29852, SQ29852, SQ 29852, CeronaprilumCas No. 111223-26-8

Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.

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Purity:97.94%

ee:100%

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Product Introduction

Bioactivity

Description	Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.
In vivo	In male SD rats, Ceronapril (SQ 29852) inhibits ACE, with ED50 values of 0.063 μM/kg and 0.53 μM/kg for intravenous injection and oral administration, respectively [1]. Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) blocks ACE in peripheral sites of rats [2].[1].
Synonyms	SQ-29852, SQ29852, SQ 29852, Ceronaprilum

Chemical Properties

Molecular Weight	440.47
Formula	C₂₁H₃₃N₂O₆P
Cas No.	111223-26-8
Smiles	C([C@@H](OP(CCCCC1=CC=CC=C1)(=O)O)CCCCN)(=O)N2[C@H](C(O)=O)CCC2
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc