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Carnostatine

Catalog No. T10684 CAS T10684

Synonyms: SAN9812

Carnostatine (SAN9812) is a potent and selective carnosinase 1 ( CN1 ) inhibitor with a K i of 11 nM for human recombinant CN1. Carnostatine may be used to increase renal carnosine concentration as a potential therapeutic modality for diabetic nephropathy (DN). [1].

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Carnostatine, CAS T10684

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Carnostatine (SAN9812) is a potent and selective carnosinase 1 ( CN1 ) inhibitor with a K i of 11 nM for human recombinant CN1. Carnostatine may be used to increase renal carnosine concentration as a potential therapeutic modality for diabetic nephropathy (DN). [1].
Targets&IC50	CN1 (human):ki： 11 nM
In vitro	Carnostatine inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. At a carnosine concentration of 200 μM, Carnostatine has an IC 50 value of 18 nM on human recombinant CN1, i.e., close to the K m of 190 μM [1].
In vivo	Subcutaneous injection of 30 mg/kg Carnostatine (SAN9812) consistently lowers CN1 activity in the bloodstream of human CN1 transgenic (TG) mice. When Carnostatine is administered alongside Carnosine, there is up to a 100-fold increase in Carnosine concentrations in both plasma and kidneys compared to CN1-overexpressing mice that have not received any treatment. The animal model used for this study involves human carnosinase (CNDP1) transgenic mice set against a BTBR wt/ob genetic background. The dosage tested includes 3 mg/kg intravenously (i.v.) or 30 mg/kg subcutaneously (s.c.), focusing on pharmacokinetic analysis. The results indicate that a single subcutaneous dose of 30 mg/kg effectively suppresses circulating CN1 activity.

Synonyms	SAN9812
Molecular Weight	256.26
Formula	C10H16N4O4
CAS No.	T10684

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Qiu J, et al. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino Acids. 2019 Jan;51(1):7-16.

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Keywords

Carnostatine T10684 Others SAN9812 SAN-9812 SAN 9812 inhibitor inhibit

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