Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 82.00 | |
10 mg | Inquiry | $ 135.00 | |
50 mg | Inquiry | $ 398.00 | |
100 mg | Inquiry | $ 575.00 |
Description | CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent. |
In vitro | CTX-0294885 is a new type of diaminopyrimidine pyrimidine, showing inhibitory activity against a variety of kinases. CTx-0294885 represents a powerful new reagent that can be used to analyze the kinase group signal network and can promote the development of targeted therapeutic strategies. Large-scale affinity purification based on CTx-0294885, followed by LC-MS / MS, can identify 235 protein kinases in MDA-MB-231 cells, including all members of the AKT family, while other AKT families have not been detected Spectral kinase inhibitor. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase enrichment can increase the number of kinase identifications to 261. Using CTx-0294885 in combination with a broad range of specific inhibitors of three other kinases, 799 high-confidence phosphate sites on 183 kinases can be identified, 10% of which are located in the activation loop and include BMP2K, MELK, HIPK2 and Phosphoric acid sites previously not reported on PRKDC. |
Synonyms | CTX-0294885 hydrochloride |
Molecular Weight | 474.39 |
Formula | C22H25Cl2N7O |
CAS No. | T19251 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 370 mg/mL (779.95 mM)
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CTX-0294885 hydrochloride (1439934-41-4 free base) T19251 Others 1439934-41-4 CTX 0294885 Hydrochloride CTX-0294885 hydrochloride CTX0294885 Hydrochloride CTX0294885 hydrochloride (1439934414 free base) CTX 0294885 hydrochloride (1439934 41 4 free base) 1439934-41-4 free base CTX-0294885 Hydrochloride inhibitor inhibit