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COG-1410 acetate

Catalog No. T30998L

Synonyms: COG-1410 acetate(878009-24-6 Free base)

COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

COG-1410 acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 113.00
5 mg	In stock	$ 297.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
500 mg	In stock	$ 2,970.00

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Purity: 99.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.
In vitro	In BV2 microglia cells, COG-1410 acetate (1-25 μM; 48 h) decreases the production and release of NO and TNFα[3].
In vivo	COG-1410 acetate (0.8 mg/kg; i.v.) improves vestibulomotor function, and decreases poststroke locomotor asymmetry, and infarct volume of the ipsilateral hemisphere in rats[1]. COG-1410 acetate (0.3-0.6 mg/kg; i.v.) exhibits significant improvement on a short-term test of vestibulomotor function and on a long-term test of spatial learning and memory in mice[3].

Synonyms	COG-1410 acetate(878009-24-6 Free base)
Molecular Weight	1468.83
Formula	C66H125N21O16

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tukhovskaya EA, et, al. COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res. 2009 Feb 15;87(3):677-82. 2. Kuai L, et, al. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019 Sep 13;13:980. 3. Laskowitz DT, et, al. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma. 2007 Jul;24(7):1093-107.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

COG-1410 acetate Apoptosis COG1410 Acetate COG 1410 Acetate COG1410 acetate COG 1410 acetate COG-1410 Acetate COG-1410 acetate(878009-24-6 Free base) inhibitor inhibit

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