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CB30865

Catalog No. T14882 CAS 206275-15-2

Synonyms: ZM 242421

CB30865 is a potent inhibitor of Nampt, an enzyme present in the NAD biosynthetic pathway.

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CB30865, CAS 206275-15-2

Pack Size	Availability	Price/USD
2 mg	5 days	$ 164.00
5 mg	5 days	$ 283.00
25 mg	10-14 weeks	$ 763.00
50 mg	10-14 weeks	$ 992.00
100 mg	10-14 weeks	$ 1,390.00
1 mL * 10 mM (in DMSO)	5 days	$ 322.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	CB30865 is a potent inhibitor of Nampt, an enzyme present in the NAD biosynthetic pathway.
In vitro	Nampt Cancer cells develop a dependence on Nampt due to increased energy requirements and the elevated activity of NAD consuming enzymes such as sirtuins and mono and poly(ADP-ribose) polymerases (PARPs).

Synonyms	ZM 242421
Molecular Weight	516.39
Formula	C26H22BrN5O2
CAS No.	206275-15-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.33 mg/mL (64.54 mM), Sonication is recommended.

References and Literature

1. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt). J Med Chem. 2010 Dec 23;53(24):8734-8746. 2. Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664. 3. Bavetsias V, et al. The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent. J Med Chem. 2002 Aug 15;45(17):3692-3702. 4. Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CB30865 206275-15-2 Others CB 30865 CB-30865 ZM 242421 ZM-242421 ZM242421 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.