Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10747 is an inhibitor of the protein-protein interaction between heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) and a derivative of celastrol .1It decreases protein levels of the Hsp90-Cdc37 complex and the Hsp90-Cdc37 clients phosphorylated Akt and Cdk4 in A549 cells when used at a concentration of 5 μM. CAY10747 inhibits proliferation of A549, MCF-7, HOS, and HepG2 cells (IC50s = 0.41, 0.64, 0.9, and 0.94 μM, respectively) and induces apoptosis in A549 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 145.00 | |
5 mg | 35 days | $ 653.00 | |
10 mg | 35 days | $ 1,080.00 | |
25 mg | 35 days | $ 2,350.00 |
Description | CAY10747 is an inhibitor of the protein-protein interaction between heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) and a derivative of celastrol .1It decreases protein levels of the Hsp90-Cdc37 complex and the Hsp90-Cdc37 clients phosphorylated Akt and Cdk4 in A549 cells when used at a concentration of 5 μM. CAY10747 inhibits proliferation of A549, MCF-7, HOS, and HepG2 cells (IC50s = 0.41, 0.64, 0.9, and 0.94 μM, respectively) and induces apoptosis in A549 cells. |
Molecular Weight | 681.83 |
Formula | C42H48FNO6 |
CAS No. | 2413849-81-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 30 mg/mL
Ethanol: 1 mg/mL
DMSO: 20 mg/mL
You can also refer to dose conversion for different animals. More
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CAY10747 2413849-81-5 CAY 10747 CAY-10747 inhibitor inhibit