Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM). It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 95.00 | |
5 mg | 35 days | $ 415.00 | |
10 mg | 35 days | $ 730.00 | |
25 mg | 35 days | $ 1,590.00 |
Description | N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM). It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion. |
Synonyms | CAY10608 |
Molecular Weight | 433.35 |
Formula | C18H22Cl2N2O4S |
CAS No. | 457897-92-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 12.5 mg/mL
DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL
DMSO: 14 mg/mL
You can also refer to dose conversion for different animals. More
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CAY10608 457897-92-6 CAY 10608 CAY-10608 inhibitor inhibit