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Bremelanotide Acetate

Catalog No. T7608 CAS 1607799-13-2

Synonyms: bremelanotide, PT-141 Acetate

Bremelanotide is an agonist of Melanocortin Receptor (MCR) .

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Bremelanotide Acetate, CAS 1607799-13-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bremelanotide is an agonist of melanocortin receptor (MCR) .
In vivo	Treatment with Bremelanotide?(100 or 200 μg/kg) significantly increased proceptive solicitations in females primed with E+Por E alone (E+O) in bilevel chambers[1]
Animal Research	Bremelanotide(PT-141), a cyclic heptapeptide melanocortin analogue (Palatin Technologies, Cranbury, NJ), was dissolved in saline to obtain doses of 50, 100, and 200 μg/kg/ml, and injected s.c. 5 min before each behavioral test. An equal volume of saline was administered to control animals[1].

Synonyms	bremelanotide, PT-141 Acetate
Molecular Weight	1085.22
Formula	C52H72N14O12
CAS No.	1607799-13-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 36 mg/mL (33.17 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Pfaus JG, Shadiack A, Van Soest T,et al.Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist[J].Proc Natl Acad Sci U S A. 2004 Jul 6;101(27) 2. Clayton AH, Althof SE, Kingsberg S,et al.Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial[J].Womens Health (Lond). 2016 Jun;12(3):325-37.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bremelanotide Acetate 1607799-13-2 GPCR/G Protein Neuroscience Melanocortin Receptor inhibit PT141 bremelanotide MC Receptor PT 141 Inhibitor PT-141 PT-141 Acetate inhibitor

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