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Bimoclomol

Catalog No. T13580 CAS 130493-03-7

Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.

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Bimoclomol, CAS 130493-03-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.
In vitro	Under ischemic conditions, bimoclomol substantially boosts left ventricular developed pressure (LVDP) and cardiac output (CO), while reducing left ventricular end-diastolic pressure (LVEDP). At a concentration of 40 μM, it markedly enhances coronary flow (CF) during normoxic perfusion before ischemia and exhibits a biphasic impact on the relaxation rate. Concentrations of bimoclomol above 10 μM induce a concentration-dependent vasorelaxation (EC50: 214 μM), including against 20 mM KCl. However, it does not relax preparations precontracted with serotonin, PGF2α, or angiotensin II. Bimoclomol does not alter the stability or mRNA levels of Hsp70, but co-induces Hsp expression through sustained activation of heat shock factor-1 (HSF-1), a process ineffective in cells from HSF-1 deficient mice. It also engages directly with HSF-1, facilitating its prolonged association with DNA elements. Additionally, bimoclomol concentrations ranging from 0.1 to 10 μM improve the survival of rat neonatal cardiomyocytes and significantly raise HSP70 levels depending on exposure duration. A 24-hour pretreatment with bimoclomol notably enhances cell survival.
In vivo	In anesthetized dogs, Bimoclomol (1 and 5 mg/kg) decreases the ST-segment elevation induced by coronary occlusion by 56% and 80%, respectively [1].

Molecular Weight	297.78
Formula	C14H20ClN3O2
CAS No.	130493-03-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jednakovits A, et al. In vivo and in vitro acute cardiovascular effects of bimoclomol. Gen Pharmacol. 2000 May;34(5):363-9. 2. Hargitai J, et al. Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun. 2003 Aug 1;307(3):689-95. 3. Polakowski JS, et al. Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435(1):73-7.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Bimoclomol 130493-03-7 Others inhibitor inhibit

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