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Bay 41-4109

Catalog No. T10480L CAS 298708-81-3

BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV)(IC50 : 53 nM).

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Bay 41-4109, CAS 298708-81-3

Pack Size	Availability	Price/USD
2 mg	5 days	$ 386.00
25 mg	6-8 weeks	$ 2,270.00
50 mg	6-8 weeks	$ 2,980.00
100 mg	6-8 weeks	$ 4,180.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV)(IC50 : 53 nM).
Targets&IC50	HBV:53 nM
In vitro	BAY 41-4109 effectively accelerates and alters the direction of capsid assembly in vitro, demonstrating potent inhibitory effects on both HBV DNA release and cytoplasmic HBcAg levels, with IC50 values of 32.6 and 132 nM in HepG2.2.15 cells, respectively. Its inhibitory action on HBV DNA and HBcAg is dose-dependent, underscoring that its anti-HBV properties hinge on the rate at which HBcAg is inhibited. Additionally, BAY 41-4109 can stabilize preformed capsids, achieving a stabilization ratio of one inhibitor molecule per two dimers.
In vivo	BAY 41-4109 effectively suppresses virus production in vivo through a mechanism focusing on the viral capsid[2]. It dose-dependently decreases viral DNA in both the liver and plasma, showing efficacy on par with 3TC, and it diminishes hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic evaluations in mice reveal quick absorption, 30% bioavailability, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs[1].

Molecular Weight	395.76
Formula	C18H13ClF3N3O2
CAS No.	298708-81-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (252.68 mM), Sonication is recommended.

References and Literature

1. Weber O, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002 May;54(2):69-78. 2. Stray SJ, et al. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J Mol Recognit. 2006 Nov-Dec;19(6):542-8. 3. Wu GY, et al. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J Chemother. 2008 Aug;20(4):458-67.

Citations

1. Yang Y, Yan Y, Yin J, et al. Structure-Based Discovery of N-Sulfonylpiperidine-3-carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication. Viruses. 2022, 14(2): 348. 2. Yin J, Feng Z, Li Z, et al.Synthesis and evaluation of N-sulfonylpiperidine-3-carboxamide derivatives as capsid assembly modulators inhibiting HBV in vitro and in HBV-transgenic mice.European Journal of Medicinal Chemistry.2023: 115141.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bay 41-4109 298708-81-3 Microbiology/Virology HBV Bay 41 4109 Bay 414109 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.