Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator, attenuates the production of Aβ40 and Aβ42 by SHSY5Y neuroblastoma cells (IC50s: 7 nM and 17nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | Inquiry | Inquiry | |
500 mg | Inquiry | Inquiry |
Description | BPN-15606 besylate is a highly potent, orally active γ-secretase modulator, attenuates the production of Aβ40 and Aβ42 by SHSY5Y neuroblastoma cells (IC50s: 7 nM and 17nM). |
In vivo | BPN-15606 besylate (p.o.; 10 mg/kg, 25 mg/kg, and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice. BPN-15606 besylate (p.o.; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of Aβ42 and Aβ40 levels in rats. BPN-15606 besylate (p.o.; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following the single-dose administration and lasted for ≥24 hours in C57BL/6 mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance. |
Synonyms | BPN-15606 besylate |
Molecular Weight | 576.64 |
Formula | C29H29FN6O4S |
CAS No. | T10589 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BPN-15606 besylate (1914989-49-3 free base) T10589 Others BPN15606 besylate (1914989493 free base) BPN 15606 besylate (1914989 49 3 free base) BPN-15606 besylate 1914989-49-3 1914989-49-3 free base inhibitor inhibit