This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
BN201
Catalog No. T14693 CAS
1361200-34-1
BN201, a chemical compound, actively crosses the blood-brain barrier and activates the IGF-1 pathway, which is associated with stress response and neuron survival. It facilitates neuronal differentiation and the maturation of precursor cells into oligodendrocytes with an EC50 of 6.3 μM, in addition to promoting the myelination of new axons with an EC50 of 16.6 μM in vitro. BN201 exhibits potent neuroprotective effects[1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
BN201, a chemical compound, actively crosses the blood-brain barrier and activates the IGF-1 pathway, which is associated with stress response and neuron survival. It facilitates neuronal differentiation and the maturation of precursor cells into oligodendrocytes with an EC50 of 6.3 μM, in addition to promoting the myelination of new axons with an EC50 of 16.6 μM in vitro. BN201 exhibits potent neuroprotective effects[1].
In vitro
BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors[1]. BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner[1].
In vivo
BN201 (12.5-150 mg/kg; intraperitoneal injection; daily; for 30 days; female C57BL/6 mice) treatment shows less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo[1].
Molecular Weight
491.6
Formula
C25H38FN5O4
CAS No.
1361200-34-1
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.