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BM635 mesylate (1493762-74-5 free base)

Catalog No. T10563L2 CAS T10563L2

Synonyms: BM635 mesylate

BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).

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BM635 mesylate (1493762-74-5 free base) Chemical Structure

BM635 mesylate (1493762-74-5 free base), CAS T10563L2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
Targets&IC50	M. tuberculosis (strain H37Rv):（MIC50） 0.08 μM
In vivo	BM635 has potent MIC (0.12 μM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity (ED99: 49 mg/Kg; IC95%: 43–54 mg/Kg) [1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax: 1.62 μM) and a moderate bioavailability (46%) [2].

Synonyms	BM635 mesylate
Molecular Weight	488.61
Formula	C26H33FN2O4S
CAS No.	T10563L2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Poce G, et al. Pharmaceutical salt of BM635 with improved bioavailability. Eur J Pharm Sci. 2017 Mar 1;99:17-23.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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