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BCL6-IN-3

Catalog No. T10487 CAS 2253878-44-1

BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BCL6-IN-3, CAS 2253878-44-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 447.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,890.00
500 mg	In stock	$ 3,790.00
1 mL * 10 mM (in DMSO)	In stock	$ 687.00

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Purity: 97.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity.
Targets&IC50	Proliferation (SU-DHL4 cells):70 nM (GI50)

Molecular Weight	508.99
Formula	C24H31ClF2N6O2
CAS No.	2253878-44-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 180.0 mg/mL (353.6 mM)

References and Literature

1. Benjamin Richard, et al. BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6. Patent. WO2018215801A1.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library PPI Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BCL6-IN-3 2253878-44-1 Apoptosis DNA Damage/DNA Repair Others BCL DNA BCL-6-IN-3 BCL6IN3 BCL6 IN 3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.