store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 99.00 |
Description | BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models. |
Targets&IC50 | tetra-acetylated peptide:115 nM (Kd), tetra-acetylated peptide:157 nM, ATAD2:166 nM |
In vitro | In a TR-FRET assay, BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD, showing an IC50 of 166 nM. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM, respectively. The unprecedented isoform selectivity of BAY-850 suggests a mode of action different from those exhibited by canonical BD inhibitors[1]. |
Molecular Weight | 654.24 |
Formula | C38H44ClN5O3 |
CAS No. | 2099142-76-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <0.1 mg/mL (Insoluble)
DMSO: 50 mg/mL (76.42 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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BAY-850 2099142-76-2 Chromatin/Epigenetic Epigenetic Reader Domain BAY850 BAY 850 inhibitor inhibit