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Aztreonam

Catalog No. T1029 CAS 78110-38-0

Synonyms: SQ-26,776

Aztreonam (SQ-26,776) is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity.

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Aztreonam, CAS 78110-38-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 35.00
50 mg	In stock	$ 48.00
100 mg	In stock	$ 80.00
200 mg	In stock	$ 108.00
500 mg	In stock	$ 177.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.42%

Purity: 99.12%

Purity: 98%

Purity: 97.6%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Aztreonam (SQ-26,776) is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity.
In vitro	Aztreonam causes significant suppression of human colony forming unit-erythroid (cfu-e), burst forming unit-erythroid (bfu-e) and colony forming unit-granulocyte macrophage (cfu-gm) at both peak and trough serum concentrations in human bone marrow cells. [1] Aztreonam is hydrolyzed at measurable rates by class A beta-lactamases, a TEM-2 type penicillinase and the Proteus vulgaris cephalosporinase with a broad substraterange. Aztreonam is extremely stable as to the typical class C cephalosporinase of Citrobacter freundii, and acts as a competitive and progressive inhibitor for the beta-lactamase. [2] Aztreonam (AZT) combined with clindamycin (CLDM) has synergistic effects on Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Haemophilus influenzae, which are sensitive or quasi-sensitive to CLDM, in the presence of CLDM at MIC or sub-MIC. [3] Aztreonam reduces the cfu of some strains by 1 log unit without preserving the integrity of cystic fibrosis airway cell monolayers, while decreasing the biofilms of other clinical isolates by 4 log units and protecting the monolayers from being compromised. [4]
In vivo	Aztreonam (300 mg/kg) results in a significant decrease in the content of hepatic microsomal P450, while no significant change is observed in hepatic cytochrome b5 content and NADPH-cytochrome c (P450) reductase activity. [5]

Synonyms	SQ-26,776
Molecular Weight	435.43
Formula	C13H17N5O8S2
CAS No.	78110-38-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 9 mg/mL (20.7 mM)

DMSO: 81 mg/mL (186 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Charak BS, et al. J Antimicrob Chemother,1991, 27(1), 95-104. 2. Sakurai Y, et al. J Antibiot (Tokyo), 1990, 43(4), 403-410. 3. Deguchi K, et al. Jpn J Antibiot, 1991, 44(5), 529-537. 4. Yu Q, et al. J Antimicrob Chemother,2012, 67(11), 2673-2681. 5. Ohmori S, et al. Pharmacology,1994, 48(3), 137-142.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library EMA Approved Drug Library Microbial Natural Product Library Covalent Natural Product Library Orally Active Compound Library Anti-Bacterial Compound Library Bioactive Compound Library Anti-infective Natural Product Library ReFRAME Related Library FDA-Approved & Pharmacopeia Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aztreonam 78110-38-0 Microbiology/Virology Antibacterial Antibiotic SQ-26,776 Bacterial Inhibitor inhibit inhibitor

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